Pharmaceutical Formulation Development of Peptides and Proteins

By: Lars Hovgaard (Editor), Sven Frokjaer (Editor), Marco van de Weert (Editor)

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Hardcover | 14 November 2012 | Edition Number 2

At a Glance

Hardcover
394 Pages

Edition Type
New edition

Dimensions(cm)
23.39 x 15.6 x 2.24

Hardcover

RRP $378.00

$267.50

29%OFF

Aims to ship in 7 to 10 business days

The rapid advances in recombinant DNA technology and the increasing availability of peptides and proteins with therapeutic potential are a challenge for pharmaceutical scientists who have to formulate these compounds as drug products.

Pharmaceutical Formulation Development of Peptides and Proteins, Second Edition discusses the development of therapeutic peptides and proteins, from the production of active compounds via basic pre-formulation and formulation to the registration of the final product.

Providing integrated solutions, this book discusses:

The synthesis of peptides and the biotechnological production of proteins through recombinant DNA technology
The physicochemical characteristics and stability of peptides and proteins
The formulation of proteins as suspensions, solutions, and (mostly freeze-dried) solids
The opportunities and challenges of non-parenteral delivery of peptides and proteins
Risk factors, specifically the development of an unwanted immune response
A simulation approach to describe the fate of peptides and proteins upon administration to a biological system
The documentation required to register a protein-based drug

Scientists in the pharmaceutical industry and academia as well as postgraduate students in pharmaceutical science will find this a valuable resource.

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Preface	p. vii
Editors	p. ix
Contributors	p. xi
Peptide Synthesis	p. 1
Protein Expression	p. 17
Protein Purification	p. 35
Characterization of Therapeutic Peptides and Proteins	p. 49
Chemical Pathways of Peptide and Protein Degradation	p. 79
Physical Instability of Peptides and Proteins	p. 107
Peptide and Protein Derivatives	p. 131
Peptides and Proteins as Parenteral Solutions	p. 149
Peptides and Proteins as Parenteral Suspensions: An Overview of Design, Development, and Manufacturing Considerations	p. 193
Rational Design of Solid Protein Formulations	p. 239
Peptide and Protein Drug Delivery Systems for Nonparenteral Routes of Administration	p. 269
Immunogenicity of Therapeutic Proteins	p. 297
Biosimulation of Peptides and Proteins	p. 323
Registration of Peptides and Proteins	p. 339
Index	p. 363
Table of Contents provided by Ingram. All Rights Reserved.

Pharmaceutical Formulation Development of Peptides and Proteins

At a Glance

Hardcover

Shipping

How to return your order

Defective items

You Can Find This Book In

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11th Edition

Australia and New Zealand McKenna's Drug Handbook for Nursing and Midwifery

Australia and New Zealand 9th edition

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3rd Edition - Procedures in Cosmetic Dermatology Series

An Evidence-Based Approach to Phytochemicals and Other Dietary Factors

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Paramedic & Emergency Pharmacology Guidelines

2nd Edition

Rang & Dale's Pharmacology

10th Edition

Clinical Pharmacology During Pregnancy

2nd Edition

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The Mechanics and Pathomechanics of Human Movement 3rd Edition

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