Pregnancy, Sex Hormones and the Liver

By: H. B. Reyes, U. Leuschner, I. M. Arias

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Hardcover | 30 June 1996

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352 Pages

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Pregnancy is the main determinant of some liver diseases in humans: acute fatty liver of pregnancy, cholestasis of pregnancy, and acute liver failure in toxaemia of pregnancy. Pregnancy also modifies the natural history of other more common hepatobiliary diseases, such as cholesterol gallstones. Sex hormones (mainly oestrogens, progesterone and/or some of its metabolites) and prolactin are considered responsible for these pathological consequences and they also appear to be influential in the outcome of several other hepatobiliary disorders, in both sexes and all ages. Although these disorders and their hormonal interrelations have been clinically well characterized, their pathogenesis remains obscure from the biomolecular point of view. In recent years, novel approaches using new technologies have improved our understanding of hormone actions and metabolism, hormone receptors, metabolic pathways and their interrelations with closely related molecules, such as bile acids. This book, the proceedings of the 89th Falk Symposium, held in Santiago, Chile, 10-11 November, 1995, will help research scientists and clinicians to review basic and clinical aspects of these interactions, in order to stimulate biomedical research in a relevant and exciting area.

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You Can Find This Book In

Non-Fiction Medicine Clinical & Internal Medicine Hepatology Endocrinology Paediatric Medicine Neonatal Medicine Gynaecology & Obstetrics Materno-Fetal Medicine Gastroenterology Pre-Clinical Medicine & Basic Sciences Physiology

Metabolism

Alex Mowat 1935-1995
List of Speakers, Moderators and Scientific Organizers
Preface
Welcome
Synthesis of sex hormones	p. 3
The hypothalamic-pituitary-liver axis: growth hormone controls liver sex	p. 16
The role of sex hormones and hepatic plasma membranes in the pathogenesis of cholestasis	p. 51
Sex hormone-induced cholestasis	p. 60
Presentation of the State of the Art Lecturer	p. 66
State of the Art Lecture: Do all pathways of cholestasis lead to the canaliculus	p. 68
Prolactin and bile secretory function	p. 77
Regulatory pathway of bile acid synthesis: modulation by steroid hormones and cytokines	p. 84
Progesterone metabolism in normal human pregnancy and in patients with intrahepatic cholestasis of pregnancy	p. 91
Cholestatic disorders in childhood: treatable disorders and challenges	p. 103
The liver - the next frontier in the treatment of patients with cystic fibrosis	p. 114
Microvesicular fatty liver disorders: inborn defects of mitochondrial fatty acid oxidation?	p. 136
Total parenteral nutrition-associated cholestasis: infection as the principal risk factor in infants beyond the first month of life	p. 151
Round Table: Clinical and therapeutic aspects of liver diseases in childhood, influenced by sex hormones and bile acids	p. 157
Pregnancy in chronic liver disease	p. 165
Female sex hormones and primary biliary cirrhosis	p. 179
Pre-eclampsia and the liver	p. 187
Cholestasis of pregnancy	p. 195
Acute fatty liver of pregnancy	p. 202
Effects of ursodeoxycholic acid in experimental and human cholestasis	p. 211
Possible mode of action of ursodeoxycholic acid in the treatment of cholestatic liver diseases	p. 217
Ursodeoxycholic acid therapy in cholestasis of pregnancy	p. 223
Round Table: Liver diseases in pregnancy: new trends in diagnosis, therapy and research	p. 230
Modulation of hepatic content and biliary excretion of P-glycoproteins in hepatocellular and obstructive cholestasis	p. 239
Daunorubicin protects against estradiol-17[beta] glucuronide (E[subscript 2]17G)-induced cholestasis and inhibits ATP-dependent E[subscript 2]17G transport in canalicular liver plasma membranes (cLPM)	p. 241
Effect of ursodeoxycholic acid (UDC) treatment on hepatic glucuronidation in ethynyloestradiol-induced cholestasis	p. 243
Maternal cholestasis induces functional and morphological alterations in the neonatal rat liver	p. 245
Effects of a selenium-deficient diet on bile flow and biliary lipids composition, in the rat	p. 246
Intrahepatic cholestasis of pregnancy in cholecystectomized women: an epidemiological study	p. 248
Effect of bile acids on gallbladder emptying in pregnancy	p. 250
Sex hormones and liver tumours	p. 253
Pregnancy and gallstones	p. 267
Hepatobiliary surgery during pregnancy	p. 282
Pregnancy after liver transplantation	p. 295
Concluding remarks	p. 303
Final comments	p. 304
Ode to the Liver	p. 306
Index	p. 309
Table of Contents provided by Blackwell. All Rights Reserved.

Pregnancy, Sex Hormones and the Liver

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