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Protein Structure : Determination, Analysis, and Applications for Drug Discovery - Daniel Chasman

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Protein Structure

Name: Protein Structure
Brand: Taylor & Francis Inc
Price: 453.9 AUD
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Determination, Analysis, and Applications for Drug Discovery

By: Daniel Chasman (Editor)

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Hardcover | 18 March 2003 | Edition Number 1

At a Glance

Hardcover
576 Pages

Dimensions(cm)
22.9 x 15.2 x 3.18

Hardcover

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This text offers in-depth perspectives on every aspect of protein structure identification, assessment, characterization, and utilization, for a clear understanding of the diversity of protein shapes, variations in protein function, and structure-based drug design. The authors cover numerous high-throughput technologies as well as computational methods to study protein structures and residues. A valuable reference, this book reflects current trends in the effort to solve new structures arising from genome initiatives, details methods to detect and identify errors in the prediction of protein structural models, and outlines challenges in the conversion of routine processes into high-throughput platforms.

Industry Reviews

"well written throughout. supported by extensive citations highly recommended." ---Biotechnology Advances

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Preface	p. v
Contributors	p. xi
Introduction
Structural Biology and Structural Genomics: A Federal Agency Perspective	p. 1
Determination
Producing Proteins	p. 9
Crystallization of Membrane Proteins	p. 27
Prospects for High-Throughput Structure Determination by X-Ray Crystallography	p. 55
Prospects for High-Throughput Structure Determination of Proteins by NMR Spectroscopy	p. 95
Automated Molecular Replacement	p. 141
Comparative Protein Structure Modeling	p. 167
Rising Accuracy of Protein Secondary Structure Prediction	p. 207
Novel Fold and Ab Initio Methods for Protein Structure Generation	p. 251
Analysis
Identifying Errors in Three-Dimensional Protein Models	p. 277
Comparative Analysis and Evolutionary Classification of Protein Structures	p. 315
Automated Genome Functional Annotation for Structural Genomics	p. 349
The Importance of Structure-Based Function Annotation to Drug Discovery	p. 369
The Protein Data Bank	p. 389
The European Bioinformatics Institute Macromolecular Structure Database (E-MSD)	p. 407
Applications for Drug Discovery
Molecular Docking in Structure-Based Design	p. 417
Use of Pharmacophores in Structure-Based Drug Design	p. 453
The Structure of Human Interferon-[beta]-la (Avonex) and its Relation to Activity: A Case Study of the Use of Structural Data in the Arena of Protein Pharmaceuticals	p. 483
G-Protein-Coupled Receptors: Diverse Functions and Shared Mechanisms of Action Interpreted Through the Structure of Rhodopsin	p. 521
Functional Assessment of Amino Acid Variation Caused by Single-Nucleotide Polymorphisms: A Structural View	p. 561
Index	p. 593
Table of Contents provided by Ingram. All Rights Reserved.

Protein Structure

Determination, Analysis, and Applications for Drug Discovery

At a Glance

Hardcover

Industry Reviews

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How to return your order

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