Contributors | p. ix |
Preface | p. xi |
Ontogeny of Erythropoiesis in the Mammalian Embryo | p. 1 |
Introduction | p. 2 |
Primitive Erythropoiesis | p. 4 |
"Definitive" Erythropoiesis in the Fetus | p. 9 |
Developmental Origins of Erythropoiesis | p. 11 |
Conclusions | p. 14 |
Acknowledgments | p. 15 |
References | p. 15 |
The Erythroblastic Island | p. 23 |
Introduction | p. 24 |
Composition and Sites of Formation of Erythroblastic Islands | p. 26 |
Cell-Cell Adhesive Interactions Within Erythroblastic Islands | p. 35 |
Erythroblastic Island Functions | p. 39 |
Conclusion | p. 46 |
Acknowledgments | p. 46 |
References | p. 46 |
Epigenetic Control of Complex Loci During Erythropoiesis | p. 55 |
Introduction | p. 56 |
Utility of Analyzing Erythropoiesis to Dissect Epigenetic Mechanisms | p. 57 |
Epigenetic Control of the [beta]-like Globin Genes During Erythropoiesis | p. 58 |
Epigenetic Control of the Gataz Locus During Erythropoiesis | p. 69 |
Principles of Epigenetic Control Emerging from Studies of Erythropoiesis | p. 71 |
Acknowledgments | p. 73 |
References | p. 73 |
The Role of the Epigenetic Signal, DNA Methylation, in Gene Regulation During Erythroid Development | p. 85 |
Introduction | p. 86 |
DNA Methylation in Erythroid Cell Differentiation | p. 93 |
The [beta]-Globin Locus: A Model for the Role of DNA Methylation in Developmental Gene Regulation | p. 95 |
DNA Methylation of the Human [alpha]-Globin Locus | p. 104 |
DNA Methylation of Other Erythroid-Specific Genes | p. 106 |
Conclusions and Future Directions | p. 107 |
Acknowledgments | p. 108 |
References | p. 108 |
Three-Dimensional Organization of Gene Expression in Erythroid Cells | p. 117 |
Introduction: Three-Dimensional Studies in a Historical Context | p. 118 |
Long-Range Gene Activation and Gene Competition: DNA-Folding Matters? | p. 119 |
Novel Biochemical Approaches to Study DNA Topology: Insight into the Spatial Organization of the [beta]-Globin Locus | p. 123 |
The Functional Significance of Long-Range Interactions Between Regulatory Sequences | p. 125 |
Long-Range Contacts in Other Gene Loci | p. 127 |
Gene Positioning in the Nucleus: Spatial Coordination of Functionally Related Genes? | p. 129 |
Future Directions for Studies on Nuclear Architecture: 4C Technology | p. 132 |
References | p. 134 |
Iron Homeostasis and Erythropoiesis | p. 141 |
Introduction | p. 142 |
Iron Metabolism and Homeostasis | p. 142 |
Hepcidin | p. 147 |
Hepcidin and Erythropoeisis | p. 154 |
Conclusions | p. 158 |
References | p. 159 |
Effects of Nitric Oxide on Red Blood Cell Development and Phenotype | p. 169 |
Nitric Oxide | p. 170 |
NO Influence on Cell Differentiation | p. 180 |
NO Interaction with RBCs | p. 187 |
Effects of NO on Hemoglobin Expression | p. 192 |
Role of NO During Malaria Pathogenesis | p. 194 |
Effects of Fetal Hemoglobin Inducers on NO-cGMP Pathway | p. 195 |
Summary: NO and Erythropoiesis | p. 199 |
References | p. 200 |
Diamond Blackfan Anemia: A Disorder of Red Blood Cell Development | p. 217 |
Introduction | p. 218 |
Pathophysiology and Genetics: DBA, a Disorder of Ribosome Biosynthesis | p. 220 |
Other Diseases Linked to Defects in Ribosome Synthesis | p. 223 |
Ribosome Dysfunction and Red Blood Cell Development | p. 226 |
DBA Is a Cancer Predisposition Syndrome | p. 230 |
Treatment and Outcomes | p. 232 |
Summary | p. 235 |
References | p. 235 |
Index | p. 243 |
Contents of Previous Volumes | p. 249 |
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