Scleroderma

Foreword Stephen Katz MD, PhD, Director, NIAMS Foreword A personal view: Luke Evnin, PhD, President, SRF Preface John Varga, MD, Christopher P. Denton, PhD, FRCP, Fredrick M. Wigley, MD Section I. Introduction Chapter 1 - Historical Perspective - Christopher P. Denton, PhD, FRCP, and Carol Black Chapter 2 - Therapeutic evolution: a professor's view - Frank A. Wollheim, MD, PhD, FRCP Section II: Epidemiology, Genetics and Classification Chapter 3 - Overview: Epidemiology, Genetics and Classification - Christopher P. Denton, PhD, FRCP Chapter 4 - Epidemiology and Environmental Risk Factors - Jammie K. Barnes, MD, and Maureen D. Mayes, MD, MPH Chapter 5 - Genetic Factors - Yannick Allanore, MD, PhD, and Filemon K. Tan, MD, PhD Chapter 6 - Disease Subsets in Clinical Practice - Robyn Therese Domsic, MD, MPH, and Thomas A. Medsger, Jr., MD Chapter 7 - Evolving Concepts of Diagnosis and Classification - Lorinda Chung, MD, MS, Jaap Fransen, MD, and Frank H.J. Van den Hoogen, MD, PhD Chapter 8 - Disease Classification using Molecular Signatures - Michael L. Whitfield, PhD, and Robert Lafyatis, MD Section III: Scleroderma in Children Chapter 9 - Juvenile Localized Scleroderma - Francesco Zulian, MD Chapter 10 - Juvenile Systemic Scleroderma - Ivan Foeldvari, MD Section IV: Other Fibrosing Skin Conditions Chapter 11 - Scleroderma Mimics -Laura K. Hummers, MD, ScM Chapter 12 - Localized Forms of Scleroderma in Adults - Amy E. Gilliam, MD, and Anita C. Gilliam, MD, PhD Chapter 13 - Nephrogenic Systemic Fibrosis - Peter J. Wermuth, PhD, and Sergio A. Jimenez, MD Section V: Pathogenetic Basis Chapter 14 - Overview: Integrated Pathogenesis - John Varga, MD Chapter 15 - Immunological Mechanisms - Francisco Boin, MD, and Carlo Chizzolini, MD Chapter 16 - Innate Immunity - Keith B. Elkon, MD, and Julia J. Rhiannon, MD, MSW Chapter 17 - Autoantibodies in Pathogenesis - Kimberly Doering, BS, and Antony Rosen, MB ChB, BSc (Hons) Chapter 18 - The Clinical Aspects of Autoantibodies - John D. Pauling, BMBS, MRCP, and Neil McHugh, MB, ChB, MD, FRCP, FRCPath Chapter 19 - Mechanisms of Vascular Disease - Bashar Kalaheh, MD, and Mary Jo Mulligan-Kehoe, PhD Chapter 20 - Vascular Biomarkers - Laura K. Hummers, MD, ScM Chapter 21 - Mechanisms of Fibrosis - John Varga, MD Chapter 22 - Fibrosis: Insights from the stiff skin syndrome - Elizabeth E. Gerber, BS, and Harry C. Dietz, MD Chapter 23 - Biomarkers of Fibrosis - Christian Beyer, MD, Oliver Distler, MD, and Jorg H.W. Distler, MD Chapter 24 - Overview of Animal Models - Christopher P. Denton, PhD, FRCP, and Robert Lafyatis, MD Section VI: Cardiovascular Manifestations and Management Chapter 25 - Overview: Cardiovascular Manifestations and Management - Fredrick M. Wigley, MD Chapter 26 - Raynaud Phenomenon - Arianne Herrick and Fredrick M. Wigley, MD Chapter 27 - Nailfold Capillaroscopy - Maurizio Cutolo, MD and Vanessa Smith, MD, PhD 28SystemicVascular Disease , MD, PhD, MD, FRCP Chapter 29 - Scleroderma Renal Crisis - Christopher P. Denton, PhD, FRCP, and Virginia Steen, MD Chapter 30 - Cardiac Involvement -Sanjiv J. Shah, MD, and Andre Kahan, MD, PhD Chapter 31 - Erectile Dysfunction - Edward V. Lally, MD, Arthur L. Burnett, MD, MBA, FACS, and Trinity J. Bivalacqua, MD, PhD Section VII: Pulmonary manifestations and management Chapter 32 - Overview: Pulmonary manifestations and management - Christopher P. Denton, PhD, FRCP Chapter 33 - Clinical Assessment of Lung Disease - Greg J. Keir, MBBS, FRACP, Richard M. Silver, MD, and Athol U. Wells, MD, FRCP Chapter 34 - Computerized Tomography of Interstitial Lung Disease - Athol U. Wells, MD, FRCP, and Jonathan Goldin MD, PhD, FRCR Chapter 35 - Treatment of interstitial lung disease - Dinesh Khanna, MD, MS, and Donald P. Tashkin, MD Chapter 36 - Clinical Assessment of Pulmonary Hypertension - Harrison W. Farber, MD, Michael York, MD, Eric Hachulla, MD, PhD Chapter 37 - Treatment of Pulmonary Hypertension -Todd H. Kolb, MD, PhD, and Paul M. Hassoun, MD Chapter 38 - Complex Challenges of Pulmonary Hypertension - John Gerard Coghlan, MD, FRCP Section VIII: Gastrointestinal manifestations and management Chapter 39- Overview: Gastrointestinal Manifestations and Management - Seth Sweetser, MD, and Michael Camilleri, MD Chapter 40 - Upper Gastrointestinal Tract - John O. Clarke, MD, and Ikuo Hirano, MD Chapter 41 - Small and Large Intestinal Involvement - Philip J. Clements, MD, MPH, Terri R. Getzug, MD, and Dinesh Khanna, MD, MS Section XIX: Skin, musculoskeletal and other complications Chapter 42 - Evaluation and Management of Skin Disease - Noelle Starr Sherber, MD, FAAD Chapter 43 - Skeletal Muscle Involvement - Andrew L. Mammen, MD, PhD Chapter 44 - Tendons, Joints and Bone - Jerome Avouac, MD, PhD, and Yannick Allanore, MD, PhD Chapter 45 - Pregnancy - Virginia Steen, MD, and Eliza F. Chakravarty, MD, MS Chapter 46 - Overlooked Manifestations- Ami A. Shah, MD, MHS Section X: Disease-modifying strategies Chapter 47 -Principles of ManagementD. , MD, MPH Chapter 48 - Immunomodulatory Therapies - Jacob M. van Laar, MD, PhD Chapter 49 - Cell-Based Therapies - Alan G. Tyndall, MD, FRACP, Rheumatology FMH, and Keith M. Sullivan, MD Chapter 50 - Investigative Approaches to Drug Therapy - Voon H. Ong, PhD, MRCP, and Christopher P. Denton, PhD, FRCP Chapter 51 - Complementary and alternate medicine approaches - Judy A. Fulop, MD, MS, FABNO, and John Varga, MD Chapter 52 - Physical and occupational therapy- Luc Mouthon, MD, PhD, and Janet L. Poole, PhD, OTR/L Chapter 53 - Evaluation and Management of Psychosocial Issues - El-Baalbaki Ghassan, PhD, Lisa Jewett, BA, MSc, Jennifer A. Haythornthwaite, PhD, and Brett D. Thombs, PhD Section XI: Outcome assessment Chapter 54 - Issues in Clinical Trial Design- Suzanne Kafaja, MD, Daniel E. Furst, MD, and Janet E. Pope, MD, MPH, FRCPC Chapter 55 - Measuring Disease Activity- Dinesh Khanna, MD, MS Chapter 56 - Patient Reported Outcomes - Monique Hinchcliff, MD, and David Cella, PhD