Table of Contents
I. Basic Mechanisms of Disease:
1. Overview: Carlo Brugnara, Betty Pace
2. Genetic basis of SCD: Martin Steinberg, SweeLay Thein
3. Hemoglobin S polymerization: Daniel Kim-Shapiro, Alan Schechter, and Constance Noguchi
4. Adhesion and vaso-occlusion - the role of leukocytes: Paul Frenette,
5. Hemolysis and endothelial dysfunction: Mark Gladwin, Gregory Kato
6. Sterile inflammation and the inflammasome: Prithu Sundd, Solomon Ofori-Acquah
7. IIschemia-reperfusion injury, inflammation and oxidative stress: Robert Hebbel, John Belcher, Gregory Vercellotti
8. Mouse models of SCD and mechanisms of pain:Cheryl Hillery, Kalpna Gupta, Lewis Hsu
9. Fetal hemoglobin induction - past, present and future: Abdullah Kutlar, Griff Rodgers
II. Clinical Complications of Sickle Cell Disease:
Overview: Alexis Thompson, Ken Ataga
10. Stroke and cognitive dysfunction: Fenella Kirkham, Michael DeBaun, Robert Adams
11. Pediatric complications and newborn screening: John J. Strouse, James Casella, Nancy Green
12. Airway hyperreactivity and asthma: Claudia Morris, Liz Klings
13. Acute chest syndrome:Elliott Vichinsky, Armand Mekontso-Dessap
14. Pulmonary hypertension (PH) and critical illness: Roberto Machado, Mark Gladwin
15. Heart disease: Vandana Sachdev, Punam Malik,John Wood
16. Renal: Victor Gordeuk,Santosh Saraf, Jane Little
17. Sickle cell trait: Philippe Connes, Rakhi Naik, Hyacinth Hyacinth
18. Thrombophilia in SCD: Nigel Key, Rafal Pawlinski, Enrico Novelli
19. Acute and chronic pain: Wally Smith, Samir Ballas
20. âOrphanâ complications - leg ulcers and priapism: Caterina Minniti, Arthur Burnett
21. Ocular complications: : Adrienne Scott, Morton Goldberg
22. Rare presentations and emerging complications: Fr©d©ric Galacteros, Oswaldo Castro, Kathryn Hassell
23. Globalburden of disease: new frontiers in SCD research and care: Kwaku Ohene-Frempong, Julie Makani, Fernando Costa, Graham Serjeant,Yazdi Italia
III. EmergingTherapeutics:
Overview: David Rees, Sophie Lanzkron
24. Transfusion medicine: Anoosha Habibi, Darrell Triulzi, Miguel Abboud, Sally Campbell Lee
25. Clinical trials - state of the art and lessons learned: Ken Ataga, Laura De Castro, Marilyn Telen
26. Stem cell transplantation: John Tisdale,Courtney Fitzhugh, Mark Walters, Lakshmanan Krishnamurti
27. Emergency care â" challenges and opportunities: ClaudiaMorris
28. The psychosocial burden in SCD: MarciaTreadwell, Allison King, Julie Panepinto, Charles Jonaissant
29. Hydroxyurea and the dawn of combination therapy in SCD: Winfred Wang, Russell Ware
30. The HOLY GRAIL - Gene editing and Therapy: TimTownes, Marina Cavazzana-Calvo
Additional authors:
Joshua Field (chapter assignment TBD)