Stealth Liposomes

By: Danilo D. Lasic (Editor), Francis J. Martin (Editor)

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Hardcover | 7 April 1995 | Edition Number 1

At a Glance

Hardcover
318 Pages

Dimensions(cm)
25.4 x 17.78 x 1.91

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Examining all aspects of stealth liposomes, this book provides a historical perspective, describes liposome behavior in biological systems, and a reviews the role of glycolipid-containing liposome systems. It presents theoretical considerations followed by contributions that provide experimental verification of the various theoretical models and discusses chemistry, biology, and pharmacology. Topics include the use of sterically stabilized liposomes loaded with anticancer agent doxorubican in humans, preclinical studies in various tumors, sterically stabilized liposomes with attached antibodies, and other applications.

Industry Reviews

...a valuable account of a developing technology that may, at long last, place liposomes on the map of successful drug delivery systems." - J. Controlled Release, 35 (1995) 181-182

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Preface
Foreword
Introduction
The Editors
The Contributors
Stealth Liposomes: From Steric Stabilization to Targeting	p. 1
Fate of Liposomes in vivo and its Control: A Historical Perspective	p. 7
Effect of Surface Modification with Glycolipids and Polysaccharides on in vivo Fate of Liposomes	p. 13
Stabilization of Colloidal Dispersions by Grafted Polymers	p. 25
Physical Properties of Polymer-Grafted Bilayers	p. 35
Molecular Mechanism of Liposome and Immunoliposome Steric Protection with Poly (Ethylene Glycol): Theoretical and Experimental Proofs of the Role of Polymer Chain Flexibility	p. 51
Measurement of the Range and Magnitude of the Repulsive Pressure between PEG-Coated Liposomes	p. 63
Modulation and Modeling of Interaction Forces between Lipid Bilayers Exposing Terminally Grafted Polymer Chains	p. 73
Polyethylene Glycol-Lipid Conjugates	p. 93
Biological Properties of Sterically Stabilized Liposomes	p. 103
Mechanism of Stealth Liposomes Accumulation in Some Pathological Tissues	p. 119
Extravasation of Stealth Liposomes into Tumors: Direct Measurement of Accumulation and Vascular Permeability Using a Skin-Flap Window Chamber	p. 127
Pharmacokinetics and Antitumor Activity of Anthracyclines Precipitated in Sterically Stabilized (Stealth) Liposomes	p. 139
Tissue Uptake and Therapeutic Effects of Stealth Doxorubicin	p. 149
Therapeutic Application of Vincristine in Conventional and Sterically Stabilized Liposomes	p. 173
Stealth Liposomes as a Drug Sustained Release System for I-[beta]-D-Arabinosylfuranosylcytosine (Cytosine Arabinoside)	p. 187
Stealth Liposomes as Carriers of Antibiotics in Infectious Diseases	p. 197
Sterically Stabilized Liposome-Encapsulated Hemoglobin	p. 211
PEG-Modified Liposomes for Gamma- and Magnetic Resonance Imaging	p. 219
Antibody-Targeted Stealth Liposomes	p. 233
Doxorubicin Encapsulated in Polyethylene-Glycol Coated Liposomes: Initial Clinical-Pharmacokinetic Studies in Solid Tumors	p. 245
Pharmacokinetics and Tumor Localization of DOX-SL (Stealth Liposomal Doxorubicin) By Comparison with Adriamycin in Patients with AIDS and Kaposi Sarcoma	p. 257
Efficacy of DOX-SL (Stealth Liposomal Doxorubicin) in the Treatment of Advanced AIDS Related Kaposi Sarcoma	p. 267
Conclusion and Afterword	p. 279
Index	p. 283
Table of Contents provided by Blackwell. All Rights Reserved.

Stealth Liposomes

At a Glance

Hardcover

Industry Reviews

Shipping

How to return your order

Defective items

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