Structural Approaches to Sequence Evolution

Molecules, Networks, Populations

By: Ugo Bastolla (Editor), Markus Porto (Editor), Eduardo Roman (Editor)

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Hardcover | 25 June 2007

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388 Pages

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23.5 x 15.24 x 1.91

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Structural requirements constrain the evolution of biological entities at all levels, from macromolecules to their networks, right up to populations of biological organisms. Classical models of molecular evolution, however, are focused at the level of the symbols - the biological sequence - rather than that of their resulting structure. Now recent advances in understanding the thermodynamics of macromolecules, the topological properties of gene networks, the organization and mutation capabilities of genomes, and the structure of populations make it possible to incorporate these key elements into a broader and deeply interdisciplinary view of molecular evolution. This book gives an account of such a new approach, through clear tutorial contributions by leading scientists specializing in the different fields involved.

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Modeling conformational flexibility and evolution of structure : RNA as an example	p. 3
Gene3D and understanding proteome evolution	p. 37
The evolution of the globins : we thought we understood it	p. 57
The structurally constrained neutral model of protein evolution	p. 75
Towards unifying protein evolution theory	p. 113
A twenty-first century view of evolution : genome system architecture, repetitive DNA, and natural genetic engineering	p. 129
Genomic changes in bacteria : from free-living to endosymbiotic life	p. 149
Molecular phylogenetics : mathematical framework and unsolved problems	p. 169
Phylogenetics and computational biology of multigene families	p. 191
SeqinR 1.0-2 : a contributed package to the R project for statistical computing devoted to biological sequences retrieval and analysis	p. 207
Evolutionary genomics of gene expression	p. 235
From biophysics to evolutionary genetics : statistical aspects of gene regulation	p. 253
Drift and selection in evolving interacting systems	p. 285
Adaptation in simple and complex fitness landscapes	p. 299
Genetic variability in RNA viruses : consequences in epidemiology and in the development of new strategies for the extinction of infectivity	p. 341
Table of Contents provided by Blackwell. All Rights Reserved.

Structural Approaches to Sequence Evolution

Molecules, Networks, Populations

At a Glance

Hardcover

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