List of Contributors
Preface
Chapter 01: The Evolving Role of Structural Biology in Drug Discovery
Chapter 02: A Structural View on Druggability: Experimental and Computational Approaches
Chapter 03: Structural Chemogenomics: Profiling Protein-Ligand Interactions in Polypharmacological Space
Chapter 04: Fragment-Based Ligand Discovery
Chapter 05: Combining Structural, Thermodynamic and Kinetic Information to Drive Hit-to-Lead Progression
Chapter 06: Allostery as Structure-Encoded Collective Dynamics: Significance in Drug Design
Chapter 07: Biophysical Assessment of Target Protein Quality in Structure-Based Drug discovery
Chapter 08: An Industrial Perspective on Protein-Ligand Complex Crystallization
Chapter 09: Membrane Protein Crystallization
Chapter 10: High-throughput Macromolecular Crystallography in Drug Discovery: Evolving in the Midst of Revolutions
Chapter 11: Assessment of Crystallographic Structure Quality and Protein - Ligand Complex Structure Validation
Chapter 12: Complementary Information from Neutron Crystallography Studies
Chapter 13: Determination of Protein Structure and Dynamics by NMR: State of the Art and Application to the Characterization of Biotherapeutics
Chapter 14: NMR Studies of Protein - Small Molecule Interactions for Drug Discovery
Chapter 15: Computational Structural Biology for Drug Discovery: Power and Limitations
Chapter 16: The Role of Structural Biology in Kinase Inhibitors Drug Discovery Success
Chapter 17: Serine Proteinases from the Blood Coagulation Cascade
Chapter 18: Epigenetic Proteins as Emerging Drug Targets
Chapter 19: Impact of Recently Determined Crystallographic Structures of GPCRs on Drug Discovery
Chapter 20: Targeting Protein-Protein Interactions Perspective
Chapter 21: Mass Spectrometry-Based Strategies for Therapeutic Antibodies Extensive Characterization and Optimization (OptimAbs)
Chapter 22: Integrating Evolution of Drug Resistance into Drug Discovery: Lessons from the Viral Proteases of HIV-1 and HCV
Chapter 23: A Comprehensive Review on Mycobacterium Tuberculosis Targets and Drug Development from a Structural Perspective
Chapter 24: Using Crystal Structures of Drug-Metabolizing Enzymes in Mechanism-Based Modeling for Drug Design
Chapter 25: Intrinsically Disordered Proteins (IDPs): Targets for the Future?
Chapter 26: Cryo-electron Microscopy as a Tool for Drug Discovery in the Context of Integrative Structural Biology
Chapter 27: Application of Hard-X-ray Free-electron Lasers for Static and Dynamic Processes in Structural Biology
