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Structure and Function of Glutathione S-Transferases

Name: Structure and Function of Glutathione S-Transferases
Brand: CRC PR INC
Price: 610.95 AUD
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By: Bengt Mannervik, Timothy J. Mantle, Kenneth D. Tew, Cecil B. Pickett

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Hardcover | 26 August 1993 | Edition Number 1

At a Glance

Hardcover
336 Pages

Dimensions(cm)
23.4 x 15.6 x 1.91

Hardcover

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Structure and Function of Glutathione S-Transferases provides some of the latest information available on a variety of structural and functional components of glutathione S-transferases, a family of isozymes involved in many endogenous and exogenous functions in cells. Molecular studies presented in the book focus on the regulation of these enzymes and identify important response elements. X-ray crystallographic structures show detailed information on the structural aspects of these proteins. Metabolism of a number of carcinogens and drugs is covered in detail, and the role that these enzymes play in governing drug resistance at the preclinical and clinical levels is discussed. The book will be excellent for biochemists, pharmacologists, oncologists, experimental therapeutic specialists, and others interested in glutathione S-transferases.

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You Can Find This Book In

Non-Fiction Nature & The Natural World Medicine Other Branches of Medicine Pharmacology Science Biology, Life Sciences Biochemistry Enzymology Clinical & Internal Medicine Diseases & Disorders Infectious & Contagious Diseases

Functions of GST
Role of Glutathione S-Transferase and Aldehyde Reductase in Resistance to Aflatoxin B[subscript 1]	p. 3
Some Functions of Glutathione Transferases	p. 15
Structural and Functional Characterization of the Binding Sites for Glutathione (G-Site) and the Hydrophobic Electrophilic Substrate (H-Site) in Glutathione Transferases	p. 29
The GST D Genes: A New Family of the Glutathione S-Transferase Gene Superfamily	p. 39
Leukotriene C[subscript 4] Synthase	p. 47
Molecular Enzymology
The Three-Dimensional Structure of Class [Pi] Glutathione S-Transferase	p. 65
The Active Site in Class Alpha Glutathione Transferases	p. 75
Crystallographic and Mechanistic Studies of Class Mu Glutathione S-Transferases	p. 87
Site-Directed Mutagenesis of Rat Glutathione S-Transferase YaYa: Structure and Function Studies	p. 99
Rat Liver Microsomal Glutathione Transferase: Studies on Structure and Function	p. 109
Gene Expression
ARE and XRE Mediated Induction of the Glutathione S-Transferase Ya Subunit Gene: Induction by Planar Aromatic Compounds and Phenolic Antioxidants	p. 119
The Role of AP-1 Transcription Factor in the Regulation of Glutathione S-Transferase Ya Subunit Gene Expression by Chemical Agents	p. 129
Polymorphic Expression of Human Glutathione Transferases	p. 137
Molecular Genetics of the Human Mu Class GST Multigene Family	p. 147
Carcinogenesis and Cancer Incidence
Evolution of GST Genes	p. 163
The Glutathione S-Transferase GSTM1 0 Locus and Cancer Susceptibility	p. 175
GST-Mediated Protection against Carcinogens: Aflatoxin B[subscript 1] Detoxification as an Example	p. 187
High Capacity Binding by Glutathione S-Transferases and Glucocorticoid Resistance	p. 199
Glutathione S-Conjugate Export Pump	p. 211
Functions of Pi-Class Glutathione S-Transferases, Roles in Carcinogenesis and Suppression by Oxidative Stress	p. 223
Resistance to Drugs and Oxidative Stress
Mechanisms through which Glutathione S-Transferase-Mediated Resistance to Alkylating Molecules Can be Augmented	p. 237
Principles of Drug Modulation Applied to Glutathione S-Transferases	p. 249
Pharmaceutical Targeting of GST Isozymes	p. 257
Glutathione Peroxidase and Resistance to Oxidative Stress	p. 269
The Organization of Human Class-Mu Glutathione Transferase Genes GSTM1-GSTM5 on Chromosome 1p13	p. 279
Mechanism of Specific Activation of Glutathione Transferase P Gene during Rat Hepatocarcinogenesis - A Transgene Study	p. 297
Index	p. 309
Table of Contents provided by Blackwell. All Rights Reserved.

Structure and Function of Glutathione S-Transferases

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Hardcover

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