Structure-Based Drug Design

AIDS

Inhibitors of HIV-1 Protease, Krzysztof Appelt A Review of Structural Studies of HIV-1 Reverse Transcriptase and Implications for Drug Design, Jianping Ding, Kalyan Das, Prem N. S. Yadav, Yu Hsiou, Wanyi Zhang, Stephen H. Hughes, and Edward Arnold Retroviral Integrase: Structure as a Foundation for Drug Design, Alison B. Hickman and Fred Dyda

Arthritis and Inflammation

Bradykinin Receptor Antagonists, Donald J. Kyle

Cancer

Design of Purine Nucleoside Phosphorylase Inhibitors, Y. Sudhakara Babu, John A. Montgomery, Charles E. Bugg, W. Michael Carson, Sthanam V. L. Narayana, William J. Cook, Steven E. Ealick, Wayne C. Guida, Mark Erion, and John Secrist III Structural Implications in the Design of Matrix-Metalloproteinase Inhibitors, John C. Spurlino Structure - Function Relationships in Hydroxysteroid Dehydrogenases, Igor Tsigelny and Michael Baker Design of ATP Competitive Specific Inhibitors of Protein Kinases Using Template Modeling, Janusz M. Sowadski, Charles A. Ellis, Rolf Karlsson, and Madhusudan

Diabetes Mellitis

Structural Studies of Aldose Reductase Inhibition, David K. Wilson, J. Mark Petrash, and Florante A. Quiocho

Heart Diseases

Structure-Based Design of Thrombin Inhibitors, Patricia C. Weber and Michael Czarniecki Design of Antithrombotic Agents Directed at Factor Xa, William C. Ripka Polypeptide Modulators of Sodium Channel Function as a Basis for the Development of Novel Cardiac Stimulants, Raymond S. Norton Rational Design of Renin Inhibitors, V. Dhanaraj and J. B. Cooper

Parkinson's Disease

Structural Aspects in the Inhibitor Design of Catechol O-Methyltransferase, Jukka Vidgren and Martti Ovaska

Sleeping Sickness

Antitrypanosomiasis Drug Development Based on Structures of Glycolytic Enzymes, Christopher L. M. J. Verlinde, Hidong Kim, Bradley E. Bernstein, Shekhar C. Mande, and Wim G. J. Hol

Immune Diseases and Cytokines

Progress in the Design of Immunomodulators Based on the Structure of Interleukin-1, Glen Spraggon and Pandi Veerapandian Structure and Functional Studies of Interferon: A Solid Foundation for Rational Drug Design, Michael A. Jarpe, Carol H. Pontzer, Brian E. Szente, and Howard M. Johnson

Antivirals

The Design of Anti-Influenza Virus Drugs from the X-Ray Molecular Structure of Influenza Virus Neuraminidase, Joseph N. Varghese Rhinoviral Capsid-Binding Inhibitors: Structural Basis for Understanding Rhinoviral Biology and for Drug Design, Vincent L. Giranda and Guy D. Diana

Novel Methodologies

The Integration of Structure-Based Design and Directed Combinatorial Chemistry for New Pharmaceutical Discovery, Roger Bone and F. Raymond Salemme Structure-Based Combinatorial Ligand Design, Amedeo Caflisch and Claus Ehrhardt Peptidomimetic and Neopeptide Drug Discovery: Impact on Structure-Based Drug Design, Tomi K. Sawyer