Structure-Based Drug Design - Pandi Veerapandian

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Structure-Based Drug Design

Name: Structure-Based Drug Design
Brand: Taylor & Francis Inc
Price: 331.75 AUD
Availability: BackOrder

By: Pandi Veerapandian (Editor)

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Hardcover | 1 January 1997 | Edition Number 1

At a Glance

Hardcover
664 Pages

Dimensions(cm)
23.4 x 15.6 x 3.18

Hardcover

RRP $399.00

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Introducing the most recent advances in crystallography, nuclear magnetic resonance, molecular modeling techniques, and computational combinatorial chemistry, this unique, interdisciplinary reference explains the application of three-dimensional structural information in the design of pharmaceutical drugs. Furnishing authoritative analyses by world-renowned experts, Structure-Based Drug Design discusses protein structure-based design in optimizing HIV protease inhibitors and details the biochemical, genetic, and clinical data on HIV-1 reverse transcriptase presents recent results on the high-resolution three-dimensional structure of the catalytic core domain of HIV-1 integrase as a foundation for divergent combination therapy focuses on structure-based design strategies for uncovering receptor antagonists to treat inflammatory diseases demonstrates a systematic approach to the design of inhibitory compounds in cancer treatment reviews current knowledge on the Interleukin-1 (IL-1) system and progress in the development of IL-1 modulators describes the influence of structure-based methods in designing capsid-binding inhibitors for relief of the common cold and much more!

Industry Reviews

the book is well-planned and executed, succeeding in giving the reader a fairly broad and complete overview of the many facets of structure based drug design.

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You Can Find This Book In

Non-Fiction Medicine Nursing & Ancillary Services Pharmacy & Dispensing Science Chemistry Organic Chemistry Other Branches of Medicine Pharmacology Crystallography Analytical Chemistry Magnetic Resonance

Engineering & Technology Industrial Chemistry & Manufacturing Technologies Industrial Chemistry Pharmaceutical Technology

Preface
Contributors
Inhibitors of HIV-1 Protease	p. 1
Structural Studies of HIV-1 Reverse Transcriptase and Implications for Drug Design	p. 41
Retroviral Integrase: Structure as a Foundation for Drug Design	p. 83
Bradykinin Receptor Antagonists	p. 119
Design of Purine Nucleoside Phosphorylase Inhibitors	p. 151
Structural Implications in the Design of Matrix-Metalloproteinase Inhibitors	p. 171
Structure-Function Relationships in Hydroxysteroid Dehydrogenases	p. 191
Design of ATP Competitive Specific Inhibitors of Protein Kinases Using Template Modeling	p. 213
Structural Studies of Aldose Reductase Inhibition	p. 229
Structure-Based Design of Thrombin Inhibitors	p. 247
Design of Antithrombotic Agents Directed at Factor Xa	p. 265
Polypeptide Modulators of Sodium Channel Function as a Basis for the Development of Novel Cardiac Stimulants	p. 295
Rational Design of Renin Inhibitors	p. 321
Structural Aspects in the Inhibitor Design of Catechol O-Methyltransferase	p. 343
Antitrypanosomiasis Drug Development Based on Structures of Glycolytic Enzymes	p. 365
Progress in the Design of Immunomodulators Based on the Structure of Interleukin-1	p. 395
Structure and Functional Studies of Interferon: A Solid Foundation for Rational Drug Design	p. 435
The Design of Anti-Influenza Virus Drugs from the X-Ray Molecular Structure of Influenza Virus Neuraminidase	p. 459
Rhinoviral Capsid-Binding Inhibitors: Structural Basis for Understanding Rhinoviral Biology and for Drug Design	p. 487
The Integration of Structure-Based Design and Directed Combinatorial Chemistry for New Pharmaceutical Discovery	p. 525
Structure-Based Combinatorial Ligand Design	p. 541
Peptidomimetic and Neopeptide Drug Discovery: Impact on Structure-Based Drug Design	p. 559
Index	p. 635
Table of Contents provided by Blackwell. All Rights Reserved.

Structure-Based Drug Design

At a Glance

Hardcover

Industry Reviews

Shipping

How to return your order

Defective items

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