| Provoking an Argument: Problems with Current Approaches to the Analysis of Biochemical Systems | |
| Snapshots of systems: metabolic control analysis and biotechnology in the post-genomic era | p. 3 |
| Moiety conservation and flux enhancement | p. 27 |
| On the universality of the universal method | p. 33 |
| Imposing Discipline: Manipulation of Organisms for Technological Ends | |
| Life is complicated | p. 41 |
| Regulation and redirection of metabolism: incorporating regulatory information in flux calculation | p. 49 |
| Recent development in metabolic pathway analysis and their potential implications for biotechnology and medicine | p. 57 |
| Quantifying the importance of regulatory loops in homeostatic control mechanisms: hierarchical control of DNA supercoiling | p. 67 |
| An integrated approach to the analysis of the control and regulation of cellular systems | p. 73 |
| Understanding Health and Disease: Why Organisms Behave as they do | |
| Mechanism of carcinogenesis by polycyclic aromatic hydrocarbons: aneuploidy precedes malignant transformation and occurs in all cancers | p. 83 |
| Metabolic control analysis shows how aneuploidy causes cancer | p. 99 |
| The control strength of glucokinase in hepatocytes: a predictor of metabolic defects in maturity onset diabetes of the young, type 2 | p. 109 |
| Metabolic distress associated with impaired control by alternative substrates: two examples taken from purine metabolism | p. 117 |
| Regulation of ATP supply in muscle: implications for importance of flux control coefficients and for the genesis of mitochondrial myopathies | p. 125 |
| Regulation of energy metabolism in hepatocytes | p. 131 |
| Combined NMR experimental and computer-simulation study of 2,3-bisphosphoglycerate metabolism in human erythrocytes | p. 139 |
| Taking Aim: Use of Metabolic Models to Identify Drug Targets | |
| Computational approaches to the study of biochemical pathways and metabolic control | p. 149 |
| Using metabolic control analysis to improve the selectivity and effectiveness of drugs against parasitic diseases | p. 157 |
| Computer simulation as a tool for studying metabolism and drug design | p. 165 |
| Use of metabolic control analysis to design a new strategy for cancer therapy | p. 173 |
| Facing Reality: Not just a Bag of Enzymes | |
| Implications of cytoarchitectural analysis | p. 183 |
| Probing the cell interior with NMR spectroscopy | p. 191 |
| Metabolite channelling and protein-protein interactions in the urea synthesis pathway | p. 199 |
| Intracellular distribution of glycogen synthase: Another regulatory mechanism of glycogen metabolism? | p. 207 |
| Supramolecular organization and substrate channelling in the mammalian translation system | p. 215 |
| Analysis of co-localization of glycolytic enzymes in flight muscle and its relation to muscle function in Drosophila | p. 223 |
| Thinking about Metabolism: The Relationship between Control and Regulation | |
| Metabolic control from the back benches: biochemistry towards biocomplexity | p. 235 |
| Physiological consequences of a non-regulated mutant phosphofructokinase in Escherichia coli | p. 243 |
| Time-dependent or steady-state control of metabolic systems? | p. 251 |
| Multisite modulation in the control of glycolysis: balance of supply and demand? | p. 259 |
| Exercising control when control is distributed | p. 267 |
| Metabolic control design: implications and applications | p. 275 |
| Determining elasticities in situ | p. 283 |
| Coordination and homeostasis in the response to multiple signals: role of metabolic cascades | p. 289 |
| Putting the cart before the horse: designing a metabolic system in order to understand it | p. 299 |
| Predicting the structural design of metabolic pathways: an evolutionary approach | p. 309 |
| Glycogen structure: an evolutionary view | p. 319 |
| Taking Stock: Control Analysis in the Context of Metabolic Regulation | |
| From control to regulation: a new prospect for metabolic control analysis | p. 329 |
| Metabolic control and metabolons in the millennium | p. 339 |
| In memoriam: Paul Srere, 1925-1999 | p. 347 |
| Contributors | p. 351 |
| Index | p. 355 |
| Table of Contents provided by Syndetics. All Rights Reserved. |
