| History, Wild Mice, and Genetics | |
| List of Reviewers | p. x |
| List of Contributors | p. xi |
| Foreword | p. xiii |
| Preface | p. xv |
| Building a Better Mouse: One Hundred Years of Genetics and Biology | p. 1 |
| Systematics of the genus Mus | p. 13 |
| The Secret World of Wild Mice | p. 25 |
| Breeding Systems: Considerations, Genetic Fundamentals, Genetic Background, and Strain Types | p. 53 |
| Mouse Strain and Genetic Nomenclature: an Abbreviated Guide | p. 79 |
| The Mouse Genome | p. 99 |
| Gene Mapping | p. 115 |
| Genetic Monitoring | p. 135 |
| Cytogenetics | p. 145 |
| Mouse Embryology: Research Techniques and a Comparison of Embryonic Development between Mouse and Man | p. 165 |
| Gamete and Embryo Manipulation | p. 211 |
| Chemical Mutagenesis in Mice | p. 225 |
| Gene-Specific Mutagenesis | p. 261 |
| Gene Transfer Studies Using Mouse Models | p. 267 |
| Mouse and Human Pluripotent Stem Cells | p. 281 |
| Drugs and the Mouse: Pharmacology, Pharmacogenetics, and Pharmacogenomics | p. 289 |
| Index | p. 321 |
| Diseases | |
| List of Reviewers | p. x |
| List of Contributors | p. xi |
| Foreword | p. xiii |
| Preface | p. xv |
| Viral Diseases | |
| DNA Viruses | |
| Murine Cytomegalovirus and Other Herpesviruses | p. 1 |
| Mouse Adenoviruses | p. 49 |
| Mousepox | p. 67 |
| Parvoviruses | p. 93 |
| Polyoma Viruses | p. 105 |
| RNA Viruses | |
| Mouse Hepatitis Virus | p. 141 |
| Lymphocytic Choriomeningitis Virus | p. 179 |
| Lactate Dehydrogenase-Elevating Virus | p. 215 |
| Reoviridae | p. 235 |
| Retroelements in the Mouse | p. 269 |
| Sendai Virus and Pneumonia Virus of Mice (PVM) | p. 281 |
| Cardioviruses: Encephalomyocarditis Virus and Theiler's Murine Encephalomyelitis Virus | p. 311 |
| Bacterial Diseases | |
| Chlamydial Diseases | p. 325 |
| Clostridial Species | p. 349 |
| Enterobacteriaceae, Pseudomonas aeruginosa, and Streptobacillus moniliformis | p. 365 |
| Aerobic Gram-Positive Organisms | p. 389 |
| Helicobacter Infections in Mice | p. 407 |
| Mycoplasma pulmonis, Other Murine Mycoplasmas, and Cilia-Associated Respiratory Bacillus | p. 437 |
| Pasteurellaceae | p. 469 |
| Mycotic and Parasitic Diseases | |
| Fungal Diseases in Laboratory Mice | p. 507 |
| Protozoa | p. 517 |
| Helminth Parasites of Laboratory Mice | p. 551 |
| Arthropods | p. 565 |
| Miscellaneous Diseases | |
| The Tumor Pathology of Genetically Engineered Mice: A New Approach to Molecular Pathology | p. 581 |
| Spontaneous Diseases in Commonly Used Mouse Strains | p. 623 |
| Zoonoses and Other Human Health Hazards | p. 719 |
| Index | p. 747 |
| Normative Biology, Husbandry, and Models | |
| List of Reviewers | p. x |
| List of Contributors | p. xi |
| Foreword | p. xiv |
| Preface | p. xv |
| Normative Biology | |
| Gross Anatomy | p. 1 |
| Mouse Physiology | p. 23 |
| Reproductive Biology of the Laboratory Mouse | p. 91 |
| Endocrinology: Bone as a Target Tissue for Hormonal Regulation | p. 123 |
| Hematology of the Laboratory Mouse | p. 133 |
| Clinical Chemistry of the Laboratory Mouse | p. 171 |
| Management, Techniques, and Husbandry | |
| Gnotobiotics | p. 217 |
| Management and Design: Breeding Facilities | p. 235 |
| Design and Management of Research Facilities for Mice | p. 271 |
| Nutrition | p. 321 |
| Health Delivery and Quality Assurance Programs for Mice | p. 385 |
| Environmental and Equipment Monitoring | p. 409 |
| Biomethodology and Surgical Techniques | p. 437 |
| In-Vivo Whole-Body Imaging of the Laboratory Mouse | p. 489 |
| Use of Mice in Biomedical Research | |
| Behavioral Testing | p. 513 |
| Cardiovascular Disease: Mouse Models of Atherosclerosis | p. 535 |
| Convulsive Disorders | p. 565 |
| Eye Research | p. 595 |
| Genetic Analysis of Rodent Obesity and Diabetes | p. 617 |
| Mouse Models in Aging Research | p. 637 |
| Mouse Models of Inherited Human Neurodegenerative Disease | p. 673 |
| Mouse Skin Ectodermal Organs | p. 691 |
| Quality Control Testing of Biologics | p. 731 |
| Index | p. 759 |
| Immunology | |
| List of Reviewers | p. x |
| List of Contributors | p. xi |
| Foreword | p. xiii |
| Preface | p. xv |
| Overview | p. 1 |
| The Molecular Basis of Lymphoid Architecture in the Mouse | p. 57 |
| The Biology of Toll-Like Receptors in Mice | p. 109 |
| Genomic Organization of the Mouse Major Histocompatibility Complex | p. 119 |
| Some Biological Features of Dendritic Cells in the Mouse | p. 135 |
| Mouse Models Revealed the Mechanisms for Somatic Hypermutation and Class Switch Recombination of Immunoglobulin Genes | p. 155 |
| Mouse Natural Killer Cells: Function and Activation | p. 169 |
| Cytokine-Activated JAK-STAT Signaling in the Mouse Immune System | p. 179 |
| Signal Transduction Events Regulating Integrin Function and T Cell Migration in the Mouse | p. 195 |
| Mouse Models of Negative Selection | p. 207 |
| Peripheral Tolerance of T Cells in the Mouse | p. 223 |
| The Genetics of Mouse Models of Systemic Lupus | p. 243 |
| Inhibitory Receptors and Autoimmunity in the Mouse | p. 261 |
| Mouse Models of Immunodeficiency | p. 275 |
| Mouse Models to Study the Pathogenesis of Allergic Asthma | p. 291 |
| The Mouse Trap: How Well Do Mice Model Human Immunology? | p. 303 |
| Index | p. 313 |
| Table of Contents provided by Ingram. All Rights Reserved. |
