Viral Vectors in Cancer Immunotherapy

By: Fernando Aranda Vega, Pedro Berraondo, Lorenzo Galluzzi

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eBook | 1 August 2023

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Viral Vectors in Cancer Immunotherapy, Volume 379 in the International Review of Cell and Molecular Biology presents the latest on cancer immunotherapy and how it has transformed cancer treatment through advances in immune checkpoint inhibitors and adoptive cell therapy. Chapters in this new release include Past, present and future of viral vectors in cancer immunotherapy, Alphaviruses in cancer immunotherapy, Adenoviral-based cancer gene therapy, Armored modified vaccinia Ankara in cancer immunotherapy, Strategies of Semliki Forest virus in immuno-oncology, Maraba virus in cancer immunotherapy, Oncolytic viruses in hematological malignancies, Oncolytic virus for cancer therapies: Overview and future directions, and more.

The use of genetically modified viruses allows the expression of pro-inflammatory molecules, while the immune system receives danger signals from the viruses themselves. In some cases, the virus can also induce tumor cell death. This book will review advances in virus-based cancer immunotherapy in both solid tumors and hematologic malignancies.

Provides an overview of the landscape of virotherapy for solid tumors and hematologic malignancies
Reviews advances in alphaviruses, adenoviruses, vaccinia viruses and Maraba virus
Presents lessons on how to improve viruses to enhance immune responses