Wintrobe's Clinical Hematology
15th Edition
By: Robert T. Means Jr, Daniel A. Arber , John P. Leonard MD, Bertil E. Glader
Hardcover | 27 July 2023 | Edition Number 15
At a Glance
2376 Pages
30 x 24.5 x 11
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orComprehensive in scope and thoroughly up to date, Wintrobe’s Clinical Hematology, 15th Edition, combines the biology and pathophysiology of hematology as well as the diagnosis and treatment of commonly encountered hematological disorders. Editor-in-chief Dr. Robert T. Means, Jr., along with a team of expert section editors and contributing authors, provide authoritative, in-depth information on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them. Packed with more than 1,500 tables and figures throughout, this trusted text is an indispensable reference for hematologists, oncologists, residents, nurse practitioners, and pathologists.
- Provides expert coverage of new topics, including COVID-19, palliative care and survivorship, transitioning from pediatric to adult care, and ethical issues in hematology such as management of individuals with religious/cultural objections to transfusion
- Integrates WHO classifications of hematologic neoplasms and the latest knowledge in genetics and genomics, and includes focused chapters on hematopoietic cell transplantation, gene therapy, and immunotherapy
- Emphasizes four components of diagnosis: the morphology of the peripheral smear, bone marrow, lymph nodes, and other tissues; flow cytometry; cytogenetics; and molecular markers and mutations
- Offers fresh perspectives from new section editors Drs. John Leonard (Lymphoma) and Laura Michaelis (Leukemia/MPN), as well as numerous new contributing authors, many of whom provide international viewpoints on hematology
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About the Authors
Daniel A. Arber MD Professor and Vice Chair of Pathology, Medical Director, Anatomic Pathology and Clinical Laboratory Services, Department of Pathology, Stanford University, Stanford, CA
Bertil E. Glader MD, PhD Professor of Pediatrics, Division of Hematology/Oncology, Stanford University School of Medicine, Stanford, CA
George M. Rodgers MD, PhD Professor of Medicine and Pathology, University of Utah School of Medicine, Health Sciences Center, Veterans' Affairs Medical Center, Salt Lake City, UT; Medical Director, Coagulation Laboratory, ARUP Laboratories, Salt Lake City, UT
- Contents
- Part 1 LABORATORY HEMATOLOGY
- Contributors vi
- Preface xvii
- Acknowledgments xix
- Chapter 1 Examination of the Blood and Bone Marrow 1
- Kristi J . Smoc k
- Chapter 2 Clinical Flow Cytometry 18
- Anna Porwit
- Chapter 3 Cytogenetics 48
- Patricia T. Greipp, Jess F . Peterson, Linda B. Baughn, and Min Fang
- Chapter 4 Molecular Diagnosis in Hematology 61
- Bing Melody Zhang and J ames L. Zehnder
- SECTION 1 HEMATOPOIESIS 69
- Chapter 5 Origin and Development of Blood Cells 69
- Daniel K. Bor g er and Robert T . Means Jr .
- SECTION 2 THE ER YTHROCYTE 93
- Chapter 6 The Birth, Life, and Death of Red Blood Cells:
- Erythropoiesis, the Mature Red Blood Cell, and Cell Destruction 93
- John G. Quigley, Robert T. Means Jr., and Bertil Glader
- SECTION 3 GRANULOCYTES AND MONOCYTES 136
- Chapter 7 Neutrophilic Leukocytes 136
- Laura G. Schuettpelz and Daniel C. Link
- Chapter 8 The Human Eosinophil 168
- Manali Mukherjee , P ar ameswar an Nair , and P aig e Lacy
- Chapter 9 Mast Cells and Basophils: Ontogeny, Characteristics,
- and Functional Diversity 196
- A. Dean Befus, Marianna Kulka, Kelly M. McNagny, and Judah A. Denburg
- Chapter 10 Monocytes, Macrophages, and Dendritic Cells 208
- Matthe w Collin, V enetia Bigle y , and Flor ent Ginhoux
- SECTION 4 THE L YMPHOCYTES 233
- Chapter 11 Lymphocytes and Lymphatic Organs 233
- Christopher Y . P ark and Matthe w M. Klairmont
- Part 2 THE NORMAL HEMATOLOGIC SYSTEM
- VOLUME 1Chapter 12 B Lymphocytes 267
- Jeffrey J. Bednarski II
- Chapter 13 T Lymphocytes 288
- Justin C. Boucher, Rawan G. Faramand, and Marco L. Davila
- Chapter 14 Natural Killer and Innate Lymphoid Cells 309
- Matthew R. Lordo, Todd A. Fehniger, Bethany L. Mundy- Bosse, and Aharon G. Freud
- Chapter 15 Major Histocompatibility Complex 322
- Qiuheng Jennifer Zhang, Michelle Hickey, Maxim Rosario, Nwe Nwe Soe,
- Carrie L. Butler, Rebecca A. Sosa, J. Michael Cecka, and Elaine F . Reed
- Chapter 16 Complement System 338
- Robert A. Brodsky and Evan M. Braunstein
- SECTION 5 HEMOSTASIS 356
- Chapter 17 Megakaryocytes 356
- William Vainchenker, Najet Debili, and Hana Raslova
- Chapter 18 Platelet Structure 391
- Elisabeth M. Battinelli and Katie Maurer
- Chapter 19 Platelet Function in Hemostasis and Thrombosis 402
- David C. Calverley
- Chapter 20 Blood Coagulation and Fibrinolysis 427
- Stephen J. Everse, Thomas Orfeo, Kathleen E. Brummel- Ziedins, and Kenneth G. Mann
- Chapter 21 Endothelium: Angiogenesis and the Regulation of Hemostasis 531
- George M. Rodgers
- Part 3 TRANSFUSION MEDICINE
- Chapter 22 Red Cell, Platelet, and White Cell Antigens 540
- Eric A. Gehrie, Heather M. Smetana, and Paul M. Ness
- Chapter 23 Transfusion Medicine 558
- Mrigender Singh Virk, Suchitra Pandey, and Jennifer Andrews
- Part 4 DISORDERS OF RED BLOOD CELLS
- SECTION 1 INTRODUCTION 600
- Chapter 24 Anemia: General Considerations 600
- Robert T. Means Jr., and Bertil Glader
- SECTION 2 DISORDERS OF IRON METABOLISM 628
- Chapter 25 Iron Deficiency and Related Disorders 628
- Elizabeta Nemeth, Marie Hollenhorst, and Lawrence T. Goodnough
- Chapter 26 Sideroblastic Anemias 656
- Mark D. Fleming
- Chapter 27 Hemochromatosis 678
- James C. Barton and Charles J. Parker
- Chapter 28 Porphyrias 702
- Makiko Yasuda, John D. Phillips, and Robert J. DesnickSECTION 3 HEMOLYTIC ANEMIA 726
- Chapter 29 Hereditary Spherocytosis, Hereditary Elliptocytosis,
- and Other Disorders Associated With Abnormalities
- of the Erythrocyte Membrane 726
- Patrick G. Gallagher and Bertil Glader
- Chapter 30 Hereditary Hemolytic Anemias Due to Red Blood Cell
- Enzyme Disorders 749
- Rachael F . Grace and Bertil Glader
- Chapter 31 Autoimmune Hemolytic Anemia 770
- Richard C. Friedberg and Clara Lo
- Chapter 32 Paroxysmal Nocturnal Hemoglobinuria 792
- Charles J. Parker and Russell E. Ware
- Chapter 33 Acquired Nonimmune Hemolytic Disorders 821
- Robert T. Means Jr., and Bertil Glader
- SECTION 4 HEREDITARY DISORDERS OF HEMOGLOBIN STRUCTURE
- AND SYNTHESIS 833
- Chapter 34 Sickle Cell Anemia and Other Sickling Syndromes 833
- Parul Rai, Jane Silva Hankins, and Jeremie E. Estepp
- Chapter 35 Thalassemia Syndromes: Quantitative Disorders of Globin
- Chain Synthesis 883
- Eugene Khandros and Janet L. Kwiatkowski
- Chapter 36 Hemoglobins With Altered Oxygen Affinity, Unstable Hemoglobins,
- M- Hemoglobins, and Dyshemoglobinemias 933
- Madeleine Verhovsek and Martin H. Steinberg
- SECTION 5 OTHER RED CELL DISORDERS 945
- Chapter 37 Megaloblastic Anemias: Disorders of Impaired DNA Synthesis 945
- Sally P . Stabler
- Chapter 38 Inherited Aplastic Anemia Syndromes Germline 974
- Nina Weichert- Leahey and Akiko Shimamura
- Chapter 39 Acquired Aplastic Anemia 995
- Amy E. DeZern and Robert A. Brodsky
- Chapter 40 Red Cell Aplasia: Acquired and Congenital Disorders 1008
- Anupama Narla, Jeffrey M. Lipton, and Robert T. Means Jr.
- Chapter 41 Congenital Dyserythropoietic Anemias 1020
- Theodosia A. Kalfa, Bertil Glader, and Gary Kupfer
- Chapter 42 Anemia of Inflammation and of Systemic Disorders 1033
- Robert T. Means Jr.
- Chapter 43 Anemias During Pregnancy and the Postpartum Period 1047
- Robert T. Means Jr.
- Chapter 44 Anemias Unique to the Fetus and Neonate 1053
- Robert D. Christensen and Robin K. Ohls
- Chapter 45 Erythrocytosis 1070
- Robert T. Means Jr., and Bertil GladerSECTION 1 INTRODUCTION 1080
- Chapter 46 Diagnostic Approach to the Bleeding Disorders 1080
- George M. Rodgers
- SECTION 2 THROMBOCYTOPENIA 1095
- Chapter 47 Thrombocytopenia: Pathophysiology and Classification 1095
- George M. Rodgers
- Chapter 48 Thrombocytopenia Caused by Immunologic Platelet Destruction 1097
- David C. Calverley, Christopher McKinney, and Christiane D. Thienelt
- Chapter 49 Thrombotic Thrombocytopenic Purpura, Hemolytic- Uremic
- Syndrome, and Related Disorders 1123
- Han- Mou Tsai
- Chapter 50 Miscellaneous Causes of Thrombocytopenia 1153
- Archana M. Agarwal, and George M. Rodgers
- Chapter 51 Bleeding Disorders Caused by Vascular Abnormalities 1162
- George M. Rodgers
- Chapter 52 Thrombocytosis and Essential Thrombocythemia 1175
- Tsewang Tashi and George M. Rodgers
- Chapter 53 Qualitative Disorders of Platelet Function 1182
- Emanuela Falcinelli, Loredana Bury, and Paolo Gresele
- SECTION 3 COAGULATION DISORDERS 1202
- Chapter 54 Inherited Coagulation Disorders 1202
- Ming Y. Lim and George M. Rodgers
- Chapter 55 Acquired Coagulation Disorders 1241
- George M. Rodgers and Ming Y. Lim
- SECTION 4 THROMBOSIS 1276
- Chapter 56 Thrombosis and Antithrombotic Therapy 1276
- Stacy A. Johnson and George M. Rodgers
Part 5 DISORDERS OF HEMOSTASIS AND COAGULATION
Part 6 DISORDERS OF LEUKOCYTES, IMMUNODEFICIENCY, AND THE SPLEEN
- Chapter 57 Diagnostic Approach to Tissue Examination and Testing 1321
- Aaron C. Shaver and Adam C. Seegmiller
- Chapter 58 Neutropenia 1331
- Nathalie Javidi- Sharifi and Nancy Berliner
- Chapter 59 Qualitative Disorders of Leukocytes 1344
- Laura C. Michaelis
- Chapter 60 Lysosomal Abnormalities of the Monocyte- Macrophage System:
- Gaucher and Niemann- Pick Diseases 1359
- Margaret M. McGovern and Robert J. Desnick
- Chapter 61 Langerhans Cell Histiocytosis 1364
- Amit Rajaram and Michael M. Henry
- VOLUME 2Chapter 62 Pathology of Langerhans Cell Histiocytosis and Other
- Histiocytic Proliferations 1376
- Andrew L. Feldman
- Chapter 63 Infectious Mononucleosis and Other Epstein- Barr Virus–Related
- Disorders 1382
- Laura F . Walsh and Richard F . Ambinder
- Chapter 64 Primary Immunodeficiency Diseases 1393
- Troy R. Torgerson
- Chapter 65 Human Immunodeficiency Virus Infection 1409
- Ariela Noy and Roy M. Gulick
- Chapter 66 Disorders of the Spleen 1423
- William C. Chapman Jr., and William C. Chapman
- Chapter 67 Tumors of the Spleen 1437
- Daniel A. Arber
- Part 7 HEMATOLOGIC MALIGNANCIES
- SECTION 1 GENERAL ASPECTS 1444
- Chapter 68 Hematopoietic Neoplasms: Principles of Pathologic Diagnosis 1444
- Daniel A. Arber
- Chapter 69 Principles of Targeted Therapies for Hematologic Malignancies 1454
- Nitin Jain, Shilpa Paul, Naveen Pemmaraju, and Varsha Gandhi
- Chapter 70 Infectious Complications in Hematologic Malignancies 1468
- Markus Plate, Alexander Drelick, and Michael J. Satlin
- Chapter 71 Immunotherapy 1494
- Trisha R. Berger and Marcela V . Maus
- Chapter 72 Gene Therapy for Hematopoietic Stem Cell Disorders 1522
- Andre Larochelle
- SECTION 2 THE ACUTE LEUKEMIAS 1562
- Chapter 73 Molecular Genetics of Acute Leukemia 1562
- Ridas Juskevicius, Utpal P . Davé, and Mary Ann Thompson
- Chapter 74 Diagnosis and Classification of the Acute Leukemias and
- Myelodysplastic Syndromes 1595
- Daniel A. Arber and Attilio Orazi
- Chapter 75 Acute Lymphoblastic Leukemia in Adults 1608
- Ehab Atallah and Kristen O’Dwyer
- Chapter 76 Acute Myeloid Leukemia in Adults 1627
- Ashkan Emadi and Maria R. Baer
- Chapter 77 Acute Lymphoblastic Leukemia in Children 1667
- Maureen M. O’Brien, Alix E. Seif, and Stephen P . Hunger
- Chapter 78 Acute Myeloid Leukemia in Children 1694
- Jennifer L. Kamens, Danielle Shin, and Norman Lacayo
- Chapter 79 Acute Promyelocytic Leukemia 1721
- Yasmin M. Abaza, Martin S. Tallman, and Jessica K. Altman
- Chapter 80 Myelodysplastic Syndromes 1737
- Namrata S. Chandhok and Mikkael A. Sekeres
- Chapter 81 Clonal Hematopoiesis of Indeterminate Potential
- and Myeloid Diseases 1754SECTION 3 MYELOPROLIFERATIVE DISORDERS 1763
- Chapter 82 Pathology of the Myeloproliferative Neoplasms 1763
- Tracy I. George and Devon S. Chabot- Richards
- Chapter 83 Chronic Myeloid Leukemia 1782
- Ehab Atallah and Michael W. Deininger
- Chapter 84 Polycythemia Vera 1808
- Laura C. Michaelis and Robert T. Means Jr.
- Chapter 85 Myelofibrosis 1821
- Andrew T. Kuykendall, Srdan Verstovsek, Eric Padron, and Rami Komrokji
- Chapter 86 Eosinophilic Neoplasms and Hypereosinophilic Syndrome 1836
- Jason Gotlib
- Chapter 87 Systemic Mastocytosis 1849
- Dean D. Metcalfe, Jonathan J. Lyons, and Jason Gotlib
- SECTION 4 LYMPHOPROLIFERATIVE DISORDERS 1866
- Chapter 88 Diagnosis and Classification of Lymphomas 1866
- Pedro Horna, Ji Yuan, and Rebecca L. King
- Chapter 89 Molecular Genetic Aspects of Non- Hodgkin Lymphomas 1900
- Annette S. Kim, Scott B. Lovitch, and Mark A. Murakami
- Chapter 90 Non- Hodgkin Lymphoma in Adults 1942
- Tarsheen K. Sethi, Shalin Kothari, Erin Mulvey, Francine Foss, John P . Leonard,
- and John P . Greer
- Chapter 91 Non- Hodgkin Lymphoma in Children 1991
- Nitya Gulati and Lisa Giulino- Roth
- Chapter 92 Chronic Lymphocytic Leukemia 2010
- Sameer A. Parikh, Saad S. Kenderian, Neil E. Kay, and James B. Johnston
- Chapter 93 Hairy Cell Leukemia 2049
- James B. Johnston, Graeme R. Quest, and Michael R. Grever
- Chapter 94 Cutaneous T- Cell Lymphoma: Mycosis Fungoides
- and Sézary Syndrome 2072
- John A. Zic, Francine Foss, Eva Niklinska, and Jeff P . Zwerner
- Chapter 95 Hodgkin Lymphoma in Adults 2116
- Reid W. Merryman and Ann LaCasce
- Chapter 96 Hodgkin Lymphoma in Children 2133
- Christine Moore Smith and Debra L. Friedman
- SECTION 5 PLASMA CELL DYSCRASIAS 2144
- Chapter 97 Practical Approach to the Evaluation of Monoclonal
- Gammopathies 2144
- Taxiarchis Kourelis and Francis K. Buadi
- Chapter 98 Molecular Genetic Aspects of Plasma Cell Disorders 2152
- Peter Leif Bergsagel, Linda B. Baughn, Dragan Jevremovic, and Yan Asmann
- Chapter 99 Monoclonal Gammopathy of Undetermined Significance and
- Smoldering Multiple Myeloma 2160
- S. Vincent Rajkumar, Robert A. Kyle, and Ronald S. Go
- Chapter 100 Multiple Myeloma 2175
- Wilson I. Gonsalves, Prashant Kapoor, and Shaji K. Kumar
- Chapter 101 Immunoglobulin Light Chain Amyloidosis 2238
- Part 8 HEMATOPOIETIC CELLULAR THERAPY
- Chapter 104 Hematopoietic Cell Transplantation 2297
- Rachel B. Salit and Frederick R. Appelbaum
- Chapter 105 Hematopoietic Cell Transplantation for Nonmalignant Disorders 2314
- Mark C. Walters and Nahal Rose Lalefar
- Chapter 106 Hematopoietic Cell Transplantation for Hematologic Malignancies 2335
- Bhagirathbhai Dholaria, Jennifer Marvin-Peek, and Bipin N. Savani
- Chapter 107 Gr aft- vs- Host Disease and Gr aft- vs- T umor Response 2355
- Joseph Pidala, Brian C. Betts, Frederick L. Locke, and Claudio Anasetti
- Chapter 108 Late Effects After Hematopoietic Cell Transplantation 2371
- Paul A. Carpenter
- Index I-1
- Chapter 102 Waldenström Macroglobulinemia 2267
- Stephen M. Ansell and Rafael Fonseca
- Chapter 103 Monoclonal Gammopathies of Clinical Significance 2276
- Angela Dispenzieri, David Dingli, and Rahma Warsam
ISBN: 9781975184698
ISBN-10: 1975184696
Series: Wintrobe's Clinical Hematology
Published: 27th July 2023
Format: Hardcover
Language: English
Number of Pages: 2376
Audience: Professional and Scholarly
Publisher: Lippincott Williams & Wilkins USA
Country of Publication: US
Edition Number: 15
Dimensions (cm): 30 x 24.5 x 11
Weight (kg): 5.12
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