γδ T Cell Cancer Immunotherapy : Evidence-Based Perspectives for Clinical Translation - Marta Barisa

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γδ T Cell Cancer Immunotherapy

Evidence-Based Perspectives for Clinical Translation

By: Marta Barisa (Editor)

eBook | 1 November 2024

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?d T Cell Cancer Immunotherapy: Evidence-Based Perspectives for Clinical Translation sets out and critically discusses the current clinical and relevant preclinical ?d T cell immunotherapy landscape. In five chapters, field experts discuss the challenges facing ?d T cell oncoimmunotherapy, propose solutions, and map next steps. Particular attention is given to summarizing our understanding of the complex, translationally relevant human ?d T cell biology, the evidence basis for designing ?d T cell combination trials and data-driven perspectives on what is known—and what isn't—about ?d T cell therapeutic persistence. Various perspectives are provided on how issues of cytotoxic effector function, functional exhaustion, and cytokine addiction can be mitigated using gene engineering. A chapter is dedicated to the systematic review of all ?d T cell immunotherapy trials to date, and the cell therapy products that were used in these trials. The final chapter discusses allograft persistence-enhancement techniques in the context of ?d T cell therapy, covering lymphodepleting chemotherapy and synthetic stealth engineering. ?d T Cell Cancer Immunotherapy: Evidence-Based Perspectives for Clinical Translation gives an updated and comprehensive insight into the current state of ?dT cell immunotherapy, which is of interest to existing translational ?d T cell specialists, the proliferating range of academic scientists and commercial scientists entering the field, as well as clinicians who may encounter ?d T cell immunotherapy in the clinic, or are wishing to familiarize themselves with noncanonical lymphocyte immunotherapy.

  • Summarizes the cutting edge of oncology-relevant ?d T cell immunobiology
  • Lays out clinical successes and failures to date
  • Addresses the possible advantage of combining ?d T cell-based immunotherapy with conventional chemotherapy or checkpoint blockers
  • Provides an up-to-date and well-rounded discussion of a translationally, commercially, and scientifically relevant field
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