Interventions for Persisting Ductus Arteriosus in the Preterm Infant

Cover -- Preface -- Part I: Basics -- 1 Developmental Anatomy of the Ductus Arteriosus -- Introduction -- Embryogenesis -- Ductal Maturation -- Patent Ductus Arteriosus in Premature Infants -- Persistent Ductus Arteriosus (PDA) -- Summary -- References -- 2 Regulation of Smooth Muscle Contraction -- 3 Prostaglandin Metabolism and Effects of Inhibitors -- 4 Postnatal Circulatory Adaptation -- 5 Epidemiology of Persisting Ductus in Preterm Infants -- Congenital Anomaly or Prolonged Adaptation? -- Clinical Relevance -- Frequency Depends on Immaturity and Echocardiograph -- Individual Variability -- Conclusions -- References -- Part II: Clinical Features -- 6 Persisting Ductus Arteriosus and Respiratory Problems -- Association with Pulmonary Immaturity / Surfactant Deficiency -- Association with Pulmonary Infection / Inflammatory Response -- X-Ray Opacities -- PDA, Lung Water, and Pulmonary Hemorrhage . . 27 Lung Mechanics -- Surfactant Substitution -- Chronic Lung Disease -- Conclusions . -- References -- 7 Influence on Mesenteric Perfusion and Necrotizing Enterocolitis -- Introduction -- Mesenteric Perfusion -- Patent Ductus Arteriosus and Mesenterial Perfusion. -- Necrotizing Enterocolitis -- Patent Ductus Arteriosus and Necrotizing Enterocolitis. -- Indomethacin Intervention -- Indomethacin Versus Ibuprofen -- Conclusions -- References -- 8 Persisting Ductus Arteriosus and Intraventricular Hemorrhage -- Cerebral Perfusion -- PDA, Lung Maturity, and IVH -- Pharmacological Interventions -- Conclusions -- References -- Part III: Diagnostics -- 9 Echocardiographic Assessment -- 10 Cerebral Doppler Sonographic Measurements -- Intracranial Arteries -- Doppler Parameters -- PDA-Specific Flow Patterns -- Conclusions -- References -- Part IV: Interventions -- 11 Therapeutic Options -- Prevention of PDA -- Prophylactic Administration of Cyclooxygenase Inhibitors -- Indomethacin -- Ibuprofen -- Hamburg Ibuprofen Study -- Current Hamburg Concept of PDA Treatment -- References -- 12 Surgical Closure -- History -- Transport to the Operating Room -- Preparation for Operation in the NICU -- Perioperative Management -- Surgical Management -- Postoperative Management -- Complications -- Outcome and Complications in our Center -- Minimally Invasive Approaches -- References -- 13 Comparison of Indomethacin and Ibuprofen -- Properties of Ibuprofen -- Therapy and Prophylaxis of Patent Ductus Arteriosus -- Effects on Regional Circulation -- Pharmacokinetics . -- Conclusions -- References -- 14 Indomethacin Effects and Side Effects -- Effects -- Management of Symptomatic PDA -- Management of Asymptomatic PDA -- Prophylactic Indomethacin -- Conclusions Regarding Effects -- Side Effects -- Impairment of Renal Function -- Impairment of Cerebral Perfusion -- Abdominal Side Effects -- Interference With Blood Glucose -- Platelet Dysfunction -- Contraindications . -- Conclusions -- References . --tidtid3373.